亚博体育app

语言选择:简体 / 繁體 / English

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSIZHAOBIAOGONGGAO

解热镇痛类

注射用帕瑞昔布钠

【规    格】(1)20mg (2)40mg(按C19H18N2O4S计)

【BAO    ZHUANG】ZHONGPENGGUIBOLIGUANZHIZHUSHEJIPING,LENGDONGGANZAOZHUSHEYONGWUJUNFENMOYONGXIUHUADINGJIXIANGJIAOSAI。

                  BAOZHUANGGUIGE:1PING/HE、2PING/HE、5PING/HE、10PING/HE。

【DAN    WEI】PING

【PIZHUNWENHAO】(1)20mg:GUOYAOZHUNZIH20193380 (2)40mg:GUOYAOZHUNZIH20193381


分享:
  • 药品介绍
  • 适应症
  • 用法用量

YABOTIYUapp:ZHUSHEYONGPARUIXIBUNASHUOMINGSHU

YABOTIYUapp:QINGZIXIYUEDUSHUOMINGSHUBINGZAIYISHIZHIDAOXIASHIYONG。

YABOTIYUapp:【YAOPINMINGCHENG】TONGYONGMINGCHENG:ZHUSHEYONGPARUIXIBUNA

YABOTIYUapp:   YINGWENMINGCHENG:Parecoxib Sodium for Injection

YABOTIYUapp:   HANYUPINYIN:Zhusheyong Paruixibuna

YABOTIYUapp:【CHENG    FEN】BENPINZHUYAOCHENGFENWEIPARUIXIBUNA

   HUAXUEMINGCHENG:N-[[4-(5-JIAJI-3-BENJI-4-YIEZUOJI)BENJI]HUANGXIANJI]BINGXIANANNAYAN

YABOTIYUapp:   HUAXUEJIEGOUSHI:

 image.png

分子式:C19H17N2O4SNa

YABOTIYUapp:   FENZILIANG:392.41

YABOTIYUapp:   FU  LIAO:WUSHUILINSUANQINGERNA,LINSUAN(YONGYUDIAOJIEpHZHI)

YABOTIYUapp:【XING    ZHUANG】BENPINWEIBAISEHUOLEIBAISEDONGGANKUAIZHUANGWUHUOFENMO。

【SHI YING ZHENG】YONGYUSHOUSHUHOUTENGTONGDEDUANQIZHILIAO。ZAIJUEDINGSHIYONGXUANZEXINGHUANYANGHUAMEI-2(COX-2)YIZHIJIQIAN,YINGPINGGUHUANZHEDEZHENGTIFENGXIAN。

【规    格】(1)20mg (2)40mg(按C19H18N2O4S计)

【YONGFAYONGLIANG】TUIJIANJILIANGWEI40mgJINGMAIZHUSHE(IV)HUOJINEIZHUSHE(IM)JIYAO,SUIHOUSHIXUYAOJIANGE6~12XIAOSHIJIYU20mgHUO40mg,MEITIANZONGJILIANGBUCHAO80mg。YOUYUXUANZEXINGCOX-2YIZHIJIDEXINXUEGUANSHIJIANFASHENGFENGXIANSUIZHEJILIANGJIBAOLUSHIJIANZENGJIAERZENGJIA,YINCI,YINGJINKENENGSHIYONGZUIDUANLIAOCHENGJIZUIDIMEIRIYOUXIAOJILIANG。SHIYONGBENPINCHAOGUOSANTIANDELINCHUANGJINGYANYOUXIAN。KEZHIJIEJINXINGKUAISUJINGMAITUIZHU,HUOTONGGUOYIYOUJINGMAITONGLUJIYAO。JINEIZHUSHEYINGXUANZESHENBUJIROUHUANMANTUIZHU。YOUYUBENPINYUQITAYAOWUZAIRONGYEZHONGHUNHEKECHUXIANCHENDIAN,YINCIBULUNZAIRONGJIEHUOSHIZHUSHEGUOCHENGZHONG,BENPINYANJINYUQITAYAOWUHUNHE。RUPARUIXIBUYUQITAYAOWUSHIYONGTONGYITIAOJINGMAITONGLU,PARUIXIBURONGYEZHUSHEQIANHOUXUCAIYONGXIANGRONGRONGYECHONGFENCHONGXIJINGMAITONGLU。

   YUAPIANLEIZHENTONGYAOLIANHEYONGYAO:APIANLEIZHENTONGYAOKEYIYUPARUIXIBUTONGSHIYINGYONG,BENPINSHIYONGJILIANGCANJIANSHANGWEN。ZAISUOYOUDELINCHUANGPINGGUZHONG,PARUIXIBUSHIGUDINGJIANGESHIJIANJIYAO,ERAPIANLEIYAOWUZESHIANXUJIYAO。

   LAONIANHUANZHE:TONGCHANG,DUIYULAONIANHUANZHE(≥65SUI)BUBIJINXINGJILIANGDIAOZHENG。DANSHI,DUIYUTIZHONGDIYU50kgDELAONIANHUANZHE,BENPINDECHUSHIJILIANGYINGJIANZHICHANGGUITUIJIANJILIANGDEYIBANQIEMEIRIZUIGAOJILIANGYINGJIANZHI40mg。

   GANGONGNENGSUNSHANG:MUQIANSHANGWUYANZHONGGANGONGNENGSUNSHANGHUANZHE(Child-Pugh PINGFEN:≥10)DELINCHUANGYONGYAOJINGYAN,YINCIJINZHIZAICILEIHUANZHEZHONGSHIYONGPARUIXIBU。TONGCHANG,QINGDUGANGONGNENGSUNSHANGDEHUANZHE(Child-Pugh PINGFEN:5~6)BUBIJINXINGJILIANGDIAOZHENG。ZHONGDUGANGONGNENGSUNSHANGDEHUANZHE(Child-Pugh PINGFEN:7~9)YINGSHENYONGBENPIN,JILIANGYINGJIANZHICHANGGUITUIJIANJILIANGDEYIBANQIEMEIRIZUIGAOJILIANGJIANGZHI40mg。

   SHENGONGNENGSUNSHANG:DUIYUZHONGDUSHENGONGNENGSUNSHANG(JIGANQINGCHULV:<30ml/min)HUOYOUYETIZHULIUQINGXIANGDEHUANZHE,YINGXUANZEZUIDITUIJIANJILIANG

      KAISHIZHILIAOBINGMIQIEJIANCESHENGONGNENG。YIJUPARUIXIBUDEYAODAIDONGLIXUE,BUBIDUIQINGDUZHIZHONGDUSHENGONGNENGSUNSHANG(JIGANQINGCHULV:

YABOTIYUapp:80ml/min)DEHUANZHEJINXINGJILIANGDIAOZHENG。

   ERTONGYONGYAO:SHANGWEIQUEDING18SUIYIXIAERTONGSHIYONGPARUIXIBUDEANQUANHELIAOXIAO。MUQIANSHANGWUKEYONGSHUJU。YINCI,BUTUIJIANZAICILEIRENQUNZHONGSHIYONGPARUIXIBU。

   SHIYONGYUCHUZHI(BAOKUODIUQI)ZHIDAOSHUOMING ZHUSHEYONGPARUIXIBUNASHIYONGQIANBIXUZHONGXINPEIZHI。YOUYUBUHANFANGFUJI。YINCIYAOQIUCAIYONGWUJUNJISHUJINXINGPEIZHI。

   PEIZHIRONGJI:KEYONGYUPEIZHIZHUSHEYONGPARUIXIBUNADERONGJIBAOKUO:LVHUANARONGYE9mg/ml(0.9%);PUTAOTANGZHUSHEYE50mg/ml(5%);LVHUANA4.5mg/ml(0.45%)PUTAOTANG50mg/ml(5%)ZHUSHEYE。

   PEIZHIGUOCHENG CAIYONGWUJUNJISHUPEIZHIPARUIXIBUDONGGANFEN(JIPARUIXIBU)。QUCHUQIKOUGAI,BAOLUPARUIXIBUBOLIPINGXIANGJIAOPINGSAIDEZHONGYANGBUFEN。YONGWUJUNZHUSHEQIJIZHENTOUXIQUSHIYONGRONGJI(20mgPARUIXIBUNAYONG1mlRONGJIPEIZHI,40mgPARUIXIBUNAYONG2mlRONGJIPEIZHI),RANHOUJIANGZHENTOUCHAJINXIANGJIAOPINGSAIZHONGYANGXIANGPINGNEIZHURURONGJI。QINGQINGXUANZHUANPINGTISHIFENMOWANQUANRONGJIEBINGZAISHIYONGQIANZIXIJIANCHAPEIZHICHENGDERONGYE。JIANGPINGNEIQUANBUYAOYECHOUCHUGONGDANCIJIYAO。PEIZHIHOU,YAOYEYINGWEITOUMINGRONGYE。PARUIXIBUNARONGYEYINGZAISHIYONGQIANJINXINGMUCE,QUEDINGRONGYESHIFOUYOUBURONGXINGWEILIHUOFASHENGBIANSE。RUOGUANCHADAORONGYEFASHENGBIANSE,CHUXIANXUZHUANGWUHUOBURONGXINGWEILI,ZEBUDESHIYONG。PEIZHIHOU,PARUIXIBUNARONGYEYINGZAI24XIAOSHINEISHIYONG,FOUZEYINGFEIQI。YIJINGZHENGSHIZAI25℃TIAOJIANXIA,PEIZHIHOUYAOYE(BUDELENGZANGHUOLENGDONG)DEWULI、HUAXUEWENDINGXINGZUIZHANGKEBAOCHI24XIAOSHI。YINCI,24XIAOSHIYINGBEISHIWEIYAOWUPEIZHIHOUDEZUIZHANGYOUXIAOQI。RANER,YOUYUZHUSHECHANPINYOUWEISHENGWUGANRANDEZHONGYAOFENGXIAN,YINCIPEIZHIDERONGYEYINGLIJISHIYONG,CHUFEIRONGYEDEPEIZHISHIZAIYANGEKONGZHIDE、BINGJINGGUOYANZHENGDEWUJUNHUANJINGZHONGJINXING。CHUFEIMANZUSHANGSHUTIAOJIAN,FOUZESHIYONGZHEBIXUZAISHIYONGQIANKONGZHIQIZHUZANGSHIJIANYUTIAOJIAN。YIBANLAISHUO,ZAI25℃TIAOJIANXIABAOCUNBUYINGCHAOGUO12XIAOSHI。PEIZHIHOUDEPARUIXIBUNARONGYEWEIDENGSHENRONGYE。

   JINGMAITONGLURONGYEDEXIANGRONGXING CAIYONGSHIYONGRONGYEPEIZHIHOU,PARUIXIBUNARONGYEZHINENGYIJINGMAIZHUSHE、JIROUZHUSHE、HUOJIARUXIALIEYETIDEJINGMAITONGLUJIYAO:LVHUANAZHUSHEYE9mg/ml(0.9%) PUTAOTANGZHUSHEYE50mg/ml(5%) LVHUANA4.5mg/ml(0.45%)HEPUTAOTANG        ZHUSHEYE RUSUANLINGESHIYE YOUYUKEYIDAOZHIPARUIXIBUZAIRONGYEZHONGCHENDIAN,GUBUTUIJIANXIANGHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEHUOQITAWEILIECHURONGYEDEJINGMAITONGLUZHONGJIARUPARUIXIBU。PEIZHIHOUDEYAOYEJINGONGDANCISHIYONG。RENHEPEIZHIHOUWEISHIYONGDEYIYAOCHANPINHUOFEIQIWUPINDOUYINGDANGANZHAODANGDIYAOQIUYUYICHULI。

   YAOWUDEBUXIANGRONGXING CHU[SHIYONGYUCHUZHI(BAOKUODIUQI)ZHIDAOSHUOMING]SUOLIEYAOWUWAI,PARUIXIBUBUDEYUQITARENHEYAOWUHUNHE。BENPINBUYINGYUAPIANLEIYAOWUHUNHEYUTONGYIZHUSHEQINEIJIYAO。SHIYONGRUSUANLINGESHIYEHUOHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEPEIZHI,PARUIXIBUHUIZAIRONGYEZHONGFASHENGCHENDIAN,GUBUTUIJIANSHIYONG。BUTUIJIANSHIYONGZHUSHEYONGSHUI,YINWEIDEDAODERONGYEBUDENGSHEN。PARUIXIBUNARONGYEBUYINGZHURURENHEQITAYAOWUDEJINGMAITONGLU。PARUIXIBUNARONGYEZHUSHEQIANHOUYINGYONGXIANGRONGRONGYECHONGFENCHONGXIJINGMAITONGLU。YOUYUKEYIDAOZHIPARUIXIBUZAIRONGYEZHONGCHENDIAN,GUBUTUIJIANXIANGHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEHUOQITA[SHIYONGYUCHUZHI(BAOKUODIUQI)DEZHIDAO]ZHONGWEILIECHURONGYEDEJINGMAITONGLUZHONGJIARUPARUIXIBU。

【BULIANGFANYING】ANQUANTEXINGZONGJIE GENJUGUOWAIWENXIANBAODAO,BENPINZUICHANGJIANBULIANGFANYINGWEIEXIN。FASHENGZUIYANZHONGBULIANGFANYINGDEQINGKUANGSHAOJIANHUOHANJIAN,BAOKUOXINJIGENGSIHEYANZHONGDIXUEYADENGXINXUEGUANSHIJIAN,YIJIGUOMINFANYING、XUEGUANXINGSHUIZHONGHEYANZHONGPIFUFANYINGDENGCHAOMINSHIJIAN。GUANZHUANGDONGMAIDAQIAOSHUHOUSHIYONGBENPINZHILIAODEHUANZHE,FASHENGCILEIBULIANGFANYINGDEFENGXIANJIAOGAO,RUXINXUEGUAN/SHUANSAISHIJIAN(BAOKUOXINJIGENGSI、ZUZHONG/DUANZANXINGNAOQUEXUEFAZUO(TIA)、FEISHUANSAIYIJISHENJINGMAISHUANSAI)、SHUHOUSHENBUZUZHIGANRANYIJIXIONGGUSHANGKOUYUHEBINGFAZHENG。

   BULIANGFANYINGLIEBIAOZAI28XIANGANWEIJIDUIZHAOLINCHUANGYANJIUZHONG,5402MINGJIESHOUPARUIXIBUZHILIAODEHUANZHEZHONG,CENGBAOGAOCHUXIANYIXIABULIANGFANYING。YOUYUWUFAGENJUXIANYOUSHUJUGUJIFASHENGLV,YINCIJIANGSHANGSHIHOUJINGYANZHONGBAOGAODEBULIANGFANYINGLIEWEI“FASHENGLVWEIZHI”。ZAIMEIGEFASHENGLVLEIBIEZHONG,BULIANGFANYINGJUNANMedDRASHUYULIECHUBINGANQIYANZHONGCHENGDUJIANGXUPAILIE。

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 BUFENBULIANGFANYINGSHUOMING YIJUSHANGSHIHOUJINGYAN,CENGYOUSHIYONGFADIXIBUFASHENGZHONGDUXINGBIAOPIHUAISISONGJIEZHENGDEBAOGAO,BUNENGPAICHUSHIYONGPARUIXIBUFASHENGGAIBULIANGFANYINGDEKENENG。CIWAI,YIXIAHANJIANYANZHONGBULIANGFANYINGYUSHIYONGFEIZAITIKANGYANYAO(NSAIDs)YOUGUAN,BINGQIEBUNENGPAICHUSHIYONGPARUIXIBUFASHENGZHEIXIEBULIANGFANYINGDEKENENG:ZHIQIGUANJINGLUANHEGANYAN。

   BAOGAOKEYIDEBULIANGFANYING ZAIYAOPINHUODESHANGSHIPIZHUNHOUBAOGAOKEYIBULIANGFANYINGFEICHANGZHONGYAO,YIBIANCHIXUJIANCEYAOPINXIAOYIYUFENGXIANZHIJIANDEPINGHENG。YIWURENYUANYINGBAOGAORENHEKEYIDEBULIANGFANYING。

【JIN    JI】DUIZHUSHEYONGPARUIXIBUNAHUOXINGCHENGFENHUOFULIAOZHONGRENHECHENGFENYOUGUOMINSHIDEHUANZHE。YOUYANZHONGYAOWUGUOMINFANYINGSHI,YOUQISHIPIFUFANYING,RUStevens-JohnsonZONGHEZHENG、ZHONGDUXINGBIAOPIHUAISISONGJIEZHENG,DUOXINGXINGHONGBANDENG,HUOYIZHIDUIHUANGANLEIYAOWUCHAOMINZHE。YOUYINGYONGFEIZAITIKANGYANYAOHOUFASHENGWEICHANGDAOCHUXUEHUOCHUANKONGBINGSHIDEHUANZHE。YOUHUODONGXINGXIAOHUADAOKUIYANGHUOWEICHANGDAOCHUXUEDEHUANZHE。FUYONGASIPILINHUONSAIDs(BAOKUOCOX-2YIZHIJI)HOUCHUXIANZHIQIGUANJINGLUAN、JIXINGBIYAN、BIXIROU、XUEGUANSHENJINGXINGSHUIZHONG、QIANMAZHENYIJIQITAGUOMINFANYINGDEHUANZHE。CHUYURENSHENWANQIHUOZHENGZAIBURUDEHUANZHE。YANZHONGGANGONGNENGSUNSHANG(XUEQINGBAIDANBAI<25g/lHUOChild-PughPINGFEN≥10)HUANZHE。YANZHENGXINGCHANGBINGHUANZHE。CHONGXUEXINGXINLISHUAIJIE(NYHAII-IV)HUANZHE。JINYONGYUGUANZHUANGDONGMAIDAQIAOSHOUSHU(CABG)SHUHOUTENGTONGDEZHILIAO。YIQUEDINGDEQUEXUEXINGXINZANGJIBING,WAIZHOUDONGMAIXUEGUANHE/HUONAOXUEGUANJIBINGDEHUANZHE。

【ZHUYISHIXIANG】BENPINYIZAIKOUQIANGKE、GUKE、FUKE(ZHUYAOSHIZIGONGQIECHUSHOUSHU)YIJIGUANZHUANGDONGMAIDAQIAOSHUZHONGJINXINGLEYANJIU。DANZAIQITALEIXINGSHOUSHUZHONGDEYANJIUYOUXIAN,RUWEICHANGDAOHUOMINIAODAOSHOUSHU(CANJIAN[LINCHUANGSHIYAN])。YOUYUJINGMAIZHUSHE(IV)HEJINEIZHUSHE(IM)JIYAOYIWAIDEQITAJIYAOFANGSHI(RUGUANJIENEIJIYAO、YINGMONEIJIYAO)DEYANJIUQUEFA,YINCIBUYINGSHIYONGQITAJIYAOFANGSHI。

   YOUYUJIAOGAOJILIANGDEPARUIXIBU、QITACOX-2YIZHIJIYIJINSAIDsKENENGZENGJIABULIANGFANYINGFASHENGLV,DUIJIESHOUPARUIXIBUZHILIAODEHUANZHEZAIJILIANGZENGJIAHOUYINGJINXINGPINGGU,ZAIJILIANGZENGJIAERLIAOXIAOBINGWEISUIZHIGAISHANSHI,YINGKAOLVQITAZHILIAOXUANZE。YINGYONGBENPINCHAOGUOSANTIANDELINCHUANGJINGYANYOUXIAN(CANJIAN[LINCHUANGSHIYAN])。RUGUOZAIZHILIAOGUOCHENGZHONG,HUANZHEFASHENGXIASHURENHEQIGUANDEGONGNENGJIANTUI,YINGCAIQUSHIDANGCUOSHIBINGKAOLVTINGYONGPARUIXIBUZHILIAO。YOUYUDANWEIJILIANGBENPINDENAHANLIANGDIYU1mmol(23mg),YINCIJIBENSHANGKESHIWEI“WUNA”。GENJUKONGZHIZHENGZHUANGDEXUYAO,ZAIZUIDUANZHILIAOSHIJIANNEISHIYONGZUIDIYOUXIAOJILIANG,KEYISHIBULIANGFANYINGJIANGDAOZUIDI。

   XINXUEGUAN ZHANGQISHIYONGXUANZEXINGCOX-2YIZHIJIKEZENGJIAXINXUEGUANXITONGJIXUESHUANXIANGGUANBULIANGSHIJIANDEFENGXIAN。SHANGWEIQUEDINGDANJILIANGZHILIAODEFENGXIANCHENGDUYIJIDAOZHIFENGXIANZENGJIADEJUTIZHILIAOZHOUQI。ZHENDUIDUOZHONGCOX-2XUANZEXINGHUOFEIXUANZEXINGNSAIDsYAOWUCHIXUSHIJIANDA3NIANDELINCHUANGSHIYANXIANSHI,CILEIYAOWUKENENGYINQIYANZHONGXINXUEGUANXUESHUANXINGBULIANGSHIJIAN、XINJIGENGSIHEZUZHONGDEFENGXIANZENGJIA,QIFENGXIANKENENGSHIZHIMINGDE。SUOYOUDENSAIDs,BAOKUOCOX-2XUANZEXINGHUOFEIXUANZEXINGYAOWU,KENENGYOUXIANGSIDEFENGXIAN。YOUXINXUEGUANJIBINGHUOXINXUEGUANJIBINGWEIXIANYINSUDEHUANZHE,QIFENGXIANGENGDA。JISHIJIWANGMEIYOUXINXUEGUANZHENGZHUANG,YISHENGHEHUANZHEYEYINGDUICILEISHIJIANDEFASHENGBAOCHIJINGTI。YINGGAOZHIHUANZHEYANZHONGXINXUEGUANANQUANXINGDEZHENGZHUANGHE/HUOTIZHENGYIJIRUGUOFASHENGYINGCAIQUDEBUZHOU。HUANZHEYINGGAIJINGTIZHURUXIONGTONG、QIDUAN、WULI、YANYUHANHUDENGZHENGZHUANGHETIZHENG,ERQIEDANGYOURENHESHANGSHUZHENGZHUANGHUOTIZHENGFASHENGHOUYINGGAIMASHANGXUNQIUYISHENGBANGZHU。RUGUOHUANZHEJUYOUFASHENGXINXUEGUANSHIJIANDEGAOWEIYINSU(RU:GAOXUEYA、GAOXUEZHI、TANGNIAOBING、XIYAN),CAIYONGBENPINZHILIAOQIANYINGRENZHENQUANHENGLIYIFENGXIAN。YOUGAOXUEYAHE/HUOXINLISHUAIJIE(RUYETIZHULIUHESHUIZHONG)BINGSHIDEHUANZHEYINGSHENYONG。RUGUOHUANZHEZAIJIESHOUPARUIXIBUZHILIAOQIJIAN,TEDINGLINCHUANGZHENGZHUANGEHUA,YINGJINXINGSHIDANGJIANCHA,BINGKAOLVTINGZHIPARUIXIBUZHILIAO。CHUGUANZHUANGDONGMAIDAQIAOSHUWAI,BENPINWEIZAIXINXUEGUANXUEYUNZHONGJIANSHUZHONGJINXINGGUOYANJIU;QITASHOUSHUDEYANJIUJINNARULEASA(MEIGUOMAZUIXIEHUI)FENJIⅠ-ⅢJIDEHUANZHE。

   ASIPILINHEQITANSAIDs YOUYUXUANZEXINGCOX-2YIZHIJIQUESHAOKANGXUEXIAOBANZUOYONG,TABUNENGTIDAIASIPILINYONGYUYUFANGXINXUEGUANXUESHUANSHUANSAILEIJIBING。YINCI,ZHILIAOQIJIANBUNENGZHONGZHIKANGXUEXIAOBANZHILIAO。YUHUAFALINHUOQITAKOUFUKANGNINGXUEYAOTONGSHISHIYONGSHI,YINGYANMIGUANCHA。YINGBIMIANJIANGBENPINYUQITAFEIASIPILINDENSAIDsHEYONG。BENPINKENENGYANGAIFAREHEQITAYANZHENGZHENGZHUANG。YINGYONGNSAIDsJIBENPINDEFEILINCHUANGYANJIUZHONGJUNYOURUANZUZHIGANRANJIAZHONGDEGEANBAODAO。SHUHOUHUANZHEJIESHOUBENPINZHILIAOSHIYINGMIQIEGUANCHASHOUSHUQIEKOUSHIFOUCHUXIANGANRANJIXIANG。

   WEICHANGDAO PARUIXIBUZHILIAOZHONGCENGYOUHUANZHECHUXIANSHANGXIAOHUADAOBINGFAZHENG[CHUANKONG、KUIYANGYIJICHUXUE(PUBs)],QIZHONGYOUXIEDAOZHIYANZHONGJIEGUO。FUYONGNSAIDsDEHUANZHEKENENGYINFAWEICHANGDAOBINGFAZHENG,YINGDUIYIXIAHUANZHEJINXINGMIQIEGUANZHU:LAONIANREN,FUYONGQITANSAIDsHUOASIPILIN、TANGPIZHIJISU、XUANZEXING5-QIANGSEANZAISHEQUYIZHIJIDEHUANZHE,YINJIUDEHUANZHEHUOYOUGUOWEICHANGDAOJIBINGBINGSHI(RUKUIYANGHUOWEICHANGDAOCHUXUE)DEHUANZHE。DANGPARUIXIBUNAYUASIPILIN(BAOKUODIJILIANG)TONGSHIFUYONGSHI,HUANZHECHUXIANWEICHANGDAOBULIANGSHIJIANDEFENGXIANHUIJINYIBUZENGJIA(WEICHANGDAOKUIYANGHUOQITAWEICHANGDAOBINGFAZHENG)。ZAISHIYONGSUOYOUNSAIDsZHILIAOGUOCHENGZHONGDERENHESHIHOU,DOUKENENGCHUXIANWEICHANGDAOCHUXUE、KUIYANGHECHUANKONGDEBULIANGFANYING,QIFENGXIANKENENGSHIZHIMINGDE。ZHEIXIEBULIANGFANYINGKENENGBANYOUHUOBUBANYOUJINGSHIZHENGZHUANG,YEWULUNHUANZHESHIFOUYOUWEICHANGDAOBULIANGFANYINGSHIHUOYANZHONGDEWEICHANGSHIJIANBINGSHI。DANGHUANZHEFUYONGGAIYAOFASHENGWEICHANGDAOCHUXUEHUOKUIYANGSHI,YINGTINGYAO。LAONIANHUANZHESHIYONGNSAIDsCHUXIANBULIANGFANYINGDEPINLVZENGJIA,YOUQISHIWEICHANGDAOCHUXUEHECHUANKONG,QIFENGXIANKENENGSHIZHIMINGDE。

   PIFUFANYING SHANGSHIHOULINCHUANGJIANCEXIANSHI,JIESHOUPARUIXIBUZHILIAODEHUANZHEYOUFASHENGYANZHONGPIFUFANYINGDEBAODAO,BAOKUODUOXINGXINGHONGBAN,BOTUOXINGPIYAN,HEStevens-JohnsonZONGHEZHENG,QIZHONGYOUXIESHIZHIMINGDE。CIWAI,SHANGSHIHOULINCHUANGJIANCEXIANSHI,JIESHOUFADIXIBU(PARUIXIBUDEHUOXINGDAIXIECHANWU)DEHUANZHEYOUCHUXIANZHONGDUXINGBIAOPIHUAISISONGJIEZHENGDEZHISIXINGBAOGAO,BUNENGPAICHUSHIYONGPARUIXIBUFASHENGGAIBULIANGFANYINGDEKENENG。HUANZHEZAIZHILIAOZAOQICHUXIANSHANGSHUBULIANGSHIJIANDEFENGXIANZUIGAO,DABUFENHUANZHEZAIZHILIAOKAISHIHOUDIYIGEYUECHUXIANSHANGSHUFANYING。YISHENGYINGCAIQUSHIDANGCUOSHIJIANCEZHILIAOZHONGDERENHEYANZHONGPIFUFANYING,RUZENGJIAHUANZHEFANGSHI。YINGGAOZHIHUANZHERUGUOCHUXIANRENHETUFADEPIFUZHUANGKUANG,LIJIXIANGYISHENGBAOGAO。HUANZHEYIDANCHUXIANPIZHEN,ZHANMOSUNSHANG,HUOQITACHAOMINZHENGZHAO,YINGTINGZHIPARUIXIBUZHILIAO。HEQITAYAOWUYIYANG,BAOKUOXUANZEXINGCOX-2YIZHIJIZAINEIDENSAIDsDOUKENENGYINQIYANZHONGPIFUFANYING。DANYUQITACOX-2XUANZEXINGYIZHIJIXIANGBI,FADIXIBUYANZHONGPIFUBULIANGSHIJIANDEBAOGAOBILVGENGGAO。YOUHUANGANLEIYAOWUGUOMINSHIDEHUANZHEKENENGGENGYICHANSHENGPIFUFANYING。DANMEIYOUHUANGANLEIYAOWUGUOMINSHIDEHUANZHEYEKENENGCHANSHENGYANZHONGPIFUFANYING。

    CHAOMINFANYING GENJUSHANGSHIHOUJINGYAN,SHIYONGFADIXIBUHUOPARUIXIBUJUNKEFASHENGCHAOMINFANYING(GUOMINFANYINGHEXUEGUANXINGSHUIZHONG)。QIZHONGYIXIEFANYINGZHUYAOFASHENGZAIYOUHUANGANLEIYAOWUGUOMINSHIDEHUANZHEZHONG。YIDANCHUXIANGUOMINJIXIANG,YINGTINGZHIPARUIXIBUZHILIAO。ZAISHANGSHIHOUDESHIYONGZHONGYOUJIESHOUPARUIXIBUHOUDUANSHIJIANNEIFASHENGYANZHONGDIXUEYADEBINGLI。QIZHONGDEYIXIEBINGLISHIZAIMEIYOUGUOMINFANYINGZHENGZHAODEQINGKUANGXIAFASHENGDE。YISHENGYINGGAIZUOHAOZHILIAOYANZHONGDIXUEYADEZHUNBEI。

    TIYEZHULIU、SHUIZHONG、SHENGONGNENG HEQITAYIZHIQIANLIEXIANSUHECHENGDEYAOWUYIYANG,ZAISHIYONGPARUIXIBUDEBUFENHUANZHEZHONGCENGGUANCHADAOTIYEZHULIUJISHUIZHONGDEFASHENG。YINCI,PARUIXIBUYINGSHENYONGYUZAIXINGONGNENGBUQUAN、YICUNZAISHUIZHONGHUOQITAYOUTIYEZHULIUQINGXIANGHUOYOUYUTIYEZHULIUERJIAZHONGBINGQINGDEQINGKUANGXIA,BAOKUOZHENGZAIJIESHOULINIAOJIZHILIAOHUOQITACUNZAIDIXUERONGLIANGFENGXIANDEHUANZHE。RUGUOZHEIXIEHUANZHELINCHUANGQINGKUANGEHUA,YINGCAIQUSHIDANGCUOSHI,BAOKUOTINGYONGPARUIXIBU。SHANGSHIHOULINCHUANGJIANCECHENG,YOUJIESHOUPARUIXIBUZHILIAODEHUANZHECHUXIANJIXINGSHENGONGNENGSHUAIJIEDEBAODAO。YOUYUYIZHIQIANLIEXIANSUHECHENGKENENGDAOZHISHENGONGNENGEHUAYIJITIYEZHULIU,YINCIBENPINYONGYUSHENGONGNENGSUNSHANG、GAOXUEYA、XINZANGGONGNENGBUQUAN、GANGONGNENGSUNSHANG,YIJIQITAJUYOUTIYEZHULIUQINGXIANGDEHUANZHESHI,YINGYUYIMIQIEGUANCHA。TUOSHUIDEHUANZHEKAISHISHIYONGBENPINZHILIAOSHI,YINGYUYIMIQIEZHUYI。JIANYIXIANWEICILEIHUANZHEBUCHONGZUGOUDESHUIFEN,ZAICAIYONGBENPINZHILIAO。

   GAOXUEYA HESUOYOUNSAIDsYIYANG,PARUIXIBUKEDAOZHIXINFAGAOXUEYAHUOJIAZHONGYIYOUDEGAOXUEYA,QIZHONGDERENHEYIZHONGDOUKEYIDAOZHIXINXUEGUANSHIJIANDEFASHENGLVZENGJIA。FUYONGSAIQINLEIHUOSUIPANLINIAOJIDEHUANZHEFUYONGNSAIDsSHI,KENENGHUIYINGXIANGZHEIXIEYAOWUDELIAOXIAO。GAOXUEYAHUANZHEYINGSHENYONGPARUIXIBU。ZAIKAISHISHIYONGPARUIXIBUZHILIAOHEZHENGGEZHILIAOGUOCHENGZHONGYINGMIQIEJIANCEXUEYA。RUGUOXUEYAMINGXIANSHENGGAO,YINGKAOLVTIDAIZHILIAO。

   GANGONGNENGSUNHAI ZHONGDUGANGONGNENGSUNSHANG(Child-PughPINGFEN:7~9)DEHUANZHEJIESHOUBENPINZHILIAOSHIYINGYUYIMIQIEZHUYI。RUOHUANZHEZAIJIESHOUBENPINZHILIAOHOUCHUXIANTOUYUN、XUANYUNHUOSHISHUIDENGZHENGZHUANG,ZEYINGTINGZHIJIASHICHELIANGHUOCAOZONGJIQI。

   YUKOUFUKANGNINGXUEJIHEYONG NSAIDsYUKOUFUKANGNINGXUEJIHEYONGHUIZENGJIACHUXUEDEFENGXIAN。KOUFUKANGNINGXUEJIBAOKUOHUAFALIN/XIANGDOUSULEIJIXINXINGKOUFUKANGNINGXUEJI(LIRUAPAISHABAN、DABIJIAQUNHELIFASHABAN)。(CANJIAN[YAOWUXIANGHUZUOYONG])。

【YUNFUJIBURUQIFUNVYONGYAO】RENSHEN RENSHENWANQISHIYONGPARUIXIBU,HUAIYIYOUKENENGYINQIYANZHONGCHUSHENGQUEXIAN。YUQITAYIZHIQIANLIEXIANSUDEYAOWUYIYANG,PARUIXIBUKEDAOZHITAIERDONGMAIDAOGUANTIQIANBIHEHUOYUNFUZIGONGSHOUSUOWULI。RENSHENZHONGQIHUOWANQISHIYONGNSAIDsKENENGYINQITAIERSHENGONGNENGBUQUAN,ZHEIKENENGHUIDAOZHIYANGSHUILIANGJIANSHAO,YANZHONGSHIKEDAOZHIYANGSHUIGUOSHAO。CIYINGXIANGKENENGFASHENGYUZHILIAOKAISHIHOUBUJIU,QIETONGCHANGKENIZHUAN。DUISHIYONGNSAIDsDEYUNFU,YINGMIQIEJIANCEYANGSHUILIANG。BENPINJINYONGYURENSHENWANQICANJIAN[JINJI])。YUQITAYIZHICOX-2DEYAOWUYIYANG,BUTUIJIANYOUSHOUYUNJIHUADEFUNVSHIYONGPARUIXIBU。RENSHENHUOFENMIANQIFUNVYINGYONGPARUIXIBUDEYANJIUSHUJUBUCHONGZU。RANER,YIZHIQIANLIEXIANSUDEHECHENGKENENGDUIRENSHENCHANSHENGBULIANGYINGXIANG。LIUXINGBINGXUEYANJIUXIANSHI,RENSHENZAOQIYINGYONGQIANLIEXIANSUHECHENGMEIYIZHIJIKENENGHUIZENGJIAZIRANLIUCHANDEJIHUI。ZAIDONGWUZHONGYINGYONGQIANLIEXIANSUHECHENGMEIYIZHIJI(BAOKUOPARUIXIBU),HUIZENGJIASHOUJINGLUANZHECHUANGQIANHOUDIUSHIYIJIPEITAI-TAIZISIWANGDEFASHENG。CHUFEIBIYAO,FOUZEZAIRENSHENZAOQIHEZHONGQIBUYINGSHIYONGBENPIN。JIYUCIXINGDASHUDUXINGZUOYONGJILIANGDEYANJIUHEJIYUTUZUIDAKEPINGGUJILIANGDEYANJIUJUNXIANSHISHOUJINGLUANZHECHUANGHOUDIUSHI,WEIXIANSHIPEITAIDUXING。ZHEIYUQITAQIANLIEXIANSUHECHENGMEIYIZHIJIYIYOUDEYANJIUYIZHI。

   BURU PARUIXIBUJIQIHUOXINGDAIXIEWUJINGBURUQIDASHUDERUZHIFENMI。JIYUPOUFUCHANHOUBURUQIFUNVDANJILIANGPARUIXIBU,YOUXIANGDUISHAOLIANGPARUIXIBUJIQIHUOXINGDAIXIEWU(FADIXIBU)JINGRUZHIFENMI,RUZHIZHONGXIANGDUIDIDEJILIANGBAOLUJIYINGER(YUEWEIMUTITIZHONG-DIAOZHENGJILIANGDE1%)。ZHENGZAIBURUDEFUNVBUDESHIYONGBENPIN。YOUYUPARUIXIBUDUIBURUZHONGYINGERDEQIANZAIFENGXIAN,YINGGENJUYAOWUDUIMUQINDEZHONGYAOXINGERJUEDINGSHIFOUTINGZHIBURUHUOTINGZHIYAOWUYINGYONG。

   SHENGYU HEQITAYIZHIDEYIZHIHUANYANGHUAMEI/QIANLIEXIANSUHECHENGDEYAOWUYIYANG,DUIYOUSHOUYUNJIHUADEFUNVBUTUIJIANSHIYONGBENPIN。GENJUNSAIDsDEZUOYONGJIZHI,YINGYONGNSAIDsKENENGHUIYANCHIHUOYIZHIPAILUAN,YOUCIZAIBUFENNVXINGZHONGHUICHUXIANKENIXINGDEBUYUN。DUIYUSHOUYUNKUNNANHUOCHAZHAOBUYUNYUANYINDENVXING,YINGKAOLVTINGYONGNSAIDs,BAOKUOPARUIXIBU。

【ERTONGYONGYAO】SHANGWEIQUEDING18SUIYIXIAERTONGSHIYONGPARUIXIBUDEANQUANXINGHELIAOXIAO。MUQIANSHANGWUKEYONGSHUJU。YINCI,BUTUIJIANZAICILEIHUANZHEZHONGSHIYONGPARUIXIBU。

【LAONIANYONGYAO】LAONIANHUANZHE(≥65SUI)YINGYONGBENPINYIBANBUXUJINXINGJILIANGDIAOZHENG。DUIYUTIZHONGDIYU50kgDELAONIANHUANZHE,CHUSHIJILIANGYINGJIANZHICHANGGUITUIJIANJILIANGDEYIBANQIEMEIRIZUIGAOJILIANGYINGJIANZHI40mg。

【YAOWUXIANGHUZUOYONG】YAOXIAOXUEXIANGHUZUOYONG ZHENGZAIJIESHOUHUAFALINHUOQITAKANGNINGXUEYAOWUZHILIAODEHUANZHESHIYONGBENPIN,JIANGZENGJIAFASHENGCHUXUEBINGFAZHENGDEFENGXIAN,YOUQIZAIZHILIAOKAISHIHOUSHUTIANNEI。YINGMIQIEJIANCETONGSHIFUYONGKANGNINGXUEYAOWUHUANZHEDENINGXUEMEIYUANSHIJIANGUOJIBIAOZHUNHUABI(INR),TEBIESHIZAIKAISHISHIYONGPARUIXIBUHUODUIPARUIXIBUJINXINGJILIANGDIAOZHENGHOUSHURINEI。BENPINDUIASIPILINYIZHIXUEXIAOBANJUJIDEZUOYONGHUOCHUXUESHIJIANMEIYOUYINGXIANG。BENPINKEYIYUDIJILIANG(≤325mg)ASIPILINHEYONG。LINCHUANGYANJIUTISHI,YUQITANSAIDsYIYANG,PARUIXIBUHEDIJILIANGASIPILINHEYONGJIANGZENGJIAFASHENGXIAOHUADAOKUIYANGHUOQITAXIAOHUADAOBINGFAZHENGDEFENGXIAN。YUDANDUSHIYONGGANSUXIANGBI,PARUIXIBUYUGANSUHEYONGBUYINGXIANGGANSUDEYAOXIAOXUETEXING(HUOHUABUFENNINGXUEHUOMEISHIJIAN)。QIANLIEXIANSUSHOUDAONSAIDs(BAOKUOCOX-2YIZHIJI)YIZHIKENENGHUIJIANGDIXUEGUANJINZHANGSUZHUANHUAMEI(ACE)YIZHIJI、XUEGUANJINZHANGSUIIJIEKANGJI、βSHOUTIZUZHIJIHELINIAOJIDEZUOYONG。ZAITONGSHISHIYONGPARUIXIBUYUACEYIZHIJI、XUEGUANJINZHANGSUIIJIEKANGJI、βSHOUTIZUZHIJIJILINIAOJIDEHUANZHEZHONGYINGKAOLVZHEIZHONGYAOWUXIANGHUZUOYONG。LAONIANREN、RONGLIANGBUZUZHE(BAOKUOLINIAOJIZHILIAOZHE)HUOSHENGONGNENGSHOUSUNZHE,HEYONGFEIZAITIKANGYANYAO(BAOKUOXUANZEXINGCOX-2YIZHIJI)YUACEYIZHIJIHUOXUEGUANJINZHANGSUIIJIEKANGJISHIKENENGDAOZHISHENZANGGONGNENGJINYIBUEHUA,BAOKUOKENENGCHUXIANJIXINGSHENGONGNENGSHUAIJIE。ZHEIXIEYINGXIANGTONGCHANGSHIKENIDE。YINCI,HEYONGZHEIXIEYAOWUSHIYINGSHENZHONG。HUANZHEYINGBUCHONGZUGOUDESHUIFEN,LIANHEYONGYAOKAISHISHIJICIHOUYINGDINGQIDUIJIANCESHENGONGNENGDEBIYAOXINGJINXINGPINGGU。YOUYUNSAIDDUISHENZANGQIANLIEXIANSUDEZUOYONG,NSAIDsYUHUANBAOMEISUHUOTAKEMOSIHEYONGKEYIZENGQIANGHUANBAOMEISUHUOTAKEMOSIDESHENDUXING。RUOPARUIXIBUYUCILEIYAOWUHEYONGSHI,YINGJIANCESHENGONGNENG。BENPINKEYIHEAPIANLEIZHITONGYAOHEYONG。ZAILINCHUANGYANJIUZHONG,DANGYUPARUIXIBULIANHEYONGYAOSHI,KEYIXIANZHUJIANSHAOANXUJIYAODEAPIANLEIYAOWUDEMEIRIXUQIULIANG。

   QITAYAOWUDUIPARUIXIBU(HUOQIHUOXINGDAIXIEWUFADIXIBU)YAODAIDONGLIXUEDEZUOYONG PARUIXIBUKEKUAISUSHUIJIEWEIHUOXINGDAIXIEWUFADIXIBU。LINCHUANGYANJIUZHENGSHI,FADIXIBUDEDAIXIEZHUYAOYOUXIBAOSESUP450(CYP)3A4JI2C9TONGGONGMEIJIEDAOWANCHENG。YUFUKANGZUO(ZHUYAOSHICYP2C9YIZHIJI)HEYONGSHI,FADIXIBUDEXUEJIANGBAOLUSHUIPINGSHENGGAO(AUCSHANGSHENG62%,CmaxSHANGSHENG19%)。ZHENGZAIJIESHOUFUKANGZUOZHILIAODEHUANZHEHEBINGSHIYONGPARUIXIBU,YINGJIANGDIPARUIXIBUJILIANG。YUTONGKANGZUO(ZHUYAOSHICYP3A4YIZHIJI)HEYONGSHI,FADIXIBUDEXUEJIANGBAOLUSHUIPINGSHENGGAO(AUCSHANGSHENG38%,CmaxSHANGSHENG24%)。DANJIESHOUTONGKANGZUOZHILIAODEHUANZHEHEYONGPARUIXIBU,WUXUDIAOZHENGPARUIXIBUJILIANG。SHANGWEIDUIMEIDEYOUDAOZUOYONGJINXINGYANJIU。DANGYUMEIYOUDAOJI(RULIFUPING、BENTUOYING、KAMAXIPINGHUODISAIMISONGDENG)HEYONGSHI,KEJIASUFADIXIBUDEDAIXIEGUOCHENG。

   PARUIXIBU(HUOQIHUOXINGDAIXIECHANWUFADIXIBU)DUIQITAYAOWUYAODAIDONGLIXUEDEZUOYONG SHIYONGFADIXIBUZHILIAO(MEICI40mg,YIRILIANGCI,GONGJI7TIAN)KEDAOZHIYOUMEISHAFEN(CYP2D6DIWU)XUEJIANGNONGDUSHENGGAO3BEI。DANGPARUIXIBUYUZHUYAOJINGCYP2D6DAIXIEBINGZHILIAOJILIANGCHUANGXIAZHAIDEYAOWU(RUFUKANI、PULUOPATONGJIMEITUOLUOER)HEYONGSHIYINGMIQIEJIANCE。FADIXIBUZHILIAO(MEICI40mg,YIRILIANGCI,GONGJI7TIAN)YINQIAOMEILAZUO(CYP2C19DIWU)(MEICI40mg,YIRIYICI)XUEJIANGBAOLUSHUIPINGSHENGGAO46%,DANFADIXIBUDEXUEJIANGBAOLUSHUIPINGBUSHOUYINGXIANG。SHANGSHUJIEGUOTISHI,JINGUANFADIXIBUBUJINGCYP2C19MEIDAIXIE,DANTARENGKENENGSHIGAIMEIDEYIZHIJI。YINCI,DANGBENPINYUYIZHIDECYP2C19DIWU(LIRU:BENTUOYING、DIXIPANHUOBINGMIQIN)HEYONGSHIYINGYUMIQIEZHUYI。ZAILIANGXIANGYAODAIDONGLIXUEYAOWUXIANGHUZUOYONGYANJIUZHONG,MEIZHOUJIAANDIELINGJILIANGWENDING(5-20mg/ZHOU,DANCIKOUFUHUOJIZHU)DELEIFENGSHIXINGGUANJIEYANHUANZHE,KOUFUFADIXIBU(MEICI10mg,YIRILIANGCIHUOMEICI40mg,YIRILIANGCI)DUIWENTAISHIJIAANDIELINGDEXUEJIANGNONGDUYINGXIANGJIAOXIAOHUOWUYINGXIANG。RANER,YOUYUSHIYONGNSAIDKENENGHUIDAOZHIXUEJIANGJIAANDIELINGSHUIPINGSHENGGAO,YINCIDANGJIAANDIELINGYUNSAIDsHEYONGSHIYINGJINSHEN。DANGPARUIXIBUYUJIAANDIELINGHEYONGSHI,RENGYINGDUIJIAANDIELINGXIANGGUANDEDUXINGFANYINGJINXINGCHONGFENJIANCE。FADIXIBUYULIJIHEYONGKEDAOZHILIXUEQINGQINGCHULVJISHENZANGQINGCHULVMINGXIANXIAJIANG(FENBIEWEI25%,30%),TONGSHI,LIDEXUEQINGBAOLUSHUIPINGJIAODANDUSHIYONGLIJISHISHENGGAO34%。ZHENGZAIJIESHOULIJIZHILIAODEHUANZHE,ZAIKAISHIPARUIXIBUZHILIAOHUOZHEDIAOZHENGPARUIXIBUJILIANGSHI,YINGYANMIJIANCEQIXUEQINGZHONGDELINONGDU。DANGFADIXIBUYUGELIEBENNIAO(CYP3A4DIWU)HEYONGSHI,QIANZHEBUYINGXIANGGELIEBENNIAODEYAODAIDONGLIXUE(BAOLUSHUIPING)JIYAOXIAOXUE(XUETANGJIYIDAOSUSHUIPING)TEXING。

   ZHUSHEXINGMAZUIJI:PARUIXIBUNA40mgYUBINGBOFEN(CYP2C9DIWU)HUOMIDAZUOLUN(CYP3A4DIWU)TONGSHIJINGZHU,PARUIXIBUBUYINGXIANGJINGZHUDEBINGBOFENHUOMIDAZUOLUNDEYAODAIDONGLIXUE(DAIXIEYUBAOLUSHUIPING)JIYAOXIAOXUE(NAODIANTU、JINGSHENYUNDONGXINGCESHIYIJIDUIZHENJINGZHUANGTAIDEHUANXING)TEXING。CIWAI,DANGFADIXIBUYUMIDAZUOLUNHEBINGYONGYAOSHI,QIANZHEDUIKOUFUMIDAZUOLUNGANZANGNEIYIJIXIAOCHANGNEIYOUCYP3A4JIEDAODEDAIXIEGUOCHENGMEIYOULINCHUANGXIANZHUYINGXIANG。JINGZHUPARUIXIBUNA40mgDUIJINGZHUFENTAINIHUOAFENTAINI(CYP3A4DIWU)DEYAODAIDONGLIXUEMEIYOUXIANZHUYINGXIANG。

   XIRUXINGMAZUIJI:SHANGWEIZHENGSHIJINXINGYAOWUXIANGHUZUOYONGYANJIU。PARUIXIBUNAYUSHUQIANJIYAO,ZAITONGSHISHIYONGPARUIXIBUHEXIRUXINGMAZUIJI(YIYANGHUADANHEYIFUWAN)DEHUANZHEZHONGMEIYOUFAXIANLIANGLEIYAOWUZAIYAOXIAOXUEFANGMIANYOUXIANGHUZUOYONG。

【YAOWUGUOLIANG】PARUIXIBUGUOLIANGYINGYONGDEBULIANGSHIJIANBAODAOYUPARUIXIBUTUIJIANJILIANGXIASUOBAODAODEBULIANGSHIJIANCUNZAIXIANGGUANXING。YIDANFASHENGYAOWUGUOLIANG,YINGYUDUIZHENGCHULIYIJIZHICHIZHILIAO。XUEYETOUXIWUFACONGTINEIQINGCHUFADIXIBU。YOUYUFADIXIBUDEGAOXUEJIANGDANBAIJIEHELV,LINIAOYUJIANHUANIAOYEDEFANGFAYEWUZHUYUYAOWUPAICHU。

【LINCHUANGSHIYAN】PARUIXIBUYIZAIDUOZHONGDAXINGHEXIAOXINGSHOUSHUZHONGSHIYONG。GENJUGUOWAIWENXIANBAODAO,BENPINDELIAOXIAOYIJINGZAIKOUQIANGKE、FUKE(ZIGONGQIECHUSHU)、GUKE(XIGUANJIEYUKUANGUANJIEZHIHUAN)SHUHOUYIJIGUANZHUANGDONGMAIDAQIAOSHUHOUDEZHITONGZHILIAOZHONGDEDAOQUEREN。DANCIJINGZHUHUOJIZHUPARUIXIBU40mgHOU,7~13FENZHONGSHICHUXIANKEGANZHIDEZHITONGZUOYONG,23~39FENZHONGSHICHANSHENGJUYOULINCHUANGYIYIDEZHITONGZUOYONG,BINGYU2XIAOSHINEIDADAOZUIDAXIAOGUO。PARUIXIBU40mgDEZHITONGZUOYONGYUJIZHUTONGGESUAN60mgHUOJINGZHU30mgDEZUOYONGXIANGFANG。DANCIJIYAOHOU,BENPINZHITONGSHIJIANDEZHANGDUANYUJIYAOJILIANGJITENGTONGMOXINGYOUGUAN,FANWEIZAI6~12XIAOSHISHENZHIGENGZHANG。SHIYONGPARUIXIBUCHAOGUOSANTIAN:DADUOSHUSHIYANSHEJIWEIPARUIXIBUJIYAOBUCHAOGUO3TIAN。YOU3XIANGSUIJI、ANWEIJIDUIZHAOSHIYANFANGANYUNXUPARUIXIBUZHILIAOSHIJIANCHAOGUO3TIAN,DUIZHEIXIESHUJUJINXINGLEHUIZONGHEFENXI。676LIHUANZHEDEHUIZONGFENXIZHONG,318LIJIESHOUANWEIJI,358LIJIESHOUPARUIXIBUZHILIAO。ZAIJIESHOUPARUIXIBUZHILIAODEHUANZHEZHONG,317LIZHILIAOSHIJIAN4TIAN,32LIZHILIAOSHIJIAN5TIAN,ERJINYOU8LIZHILIAOSHIJIAN6TIAN,1LIZHILIAOSHIJIAN7TIANHUOGENGZHANGSHIJIAN。ZAIJIESHOUANWEIJIDEHUANZHEZHONG,270LISHIYONGSHIJIAN4TIAN,43LISHIYONGSHIJIAN5TIAN,ERJINYOU3LISHIYONGSHIJIAN6TIAN,2LISHIYONGSHIJIAN7TIANHUOGENGZHANGSHIJIAN。LIANGZUJUYOUXIANGSIDERENKOUTONGJIXUESHUJU。PARUIXIBUHEANWEIJIDEZHILIAOSHIJIANPINGJUNZHI(BIAOZHUNCHA)FENBIEWEI4.1(0.4 )TIANHE4.2 (0.5)TIAN,FANWEIFENBIEWEI4~7TIANHE4~9TIAN。JIESHOUPARUIXIBUZHILIAO4~7TIAN(ZHONGWEISHIJIAN4TIAN)DEHUANZHE,ZAIZHILIAODI3TIANHOUDEBULIANGSHIJIANFASHENGLVJIAODI,YUANWEIJIZUXIANGSI。

   DUIAPIANLEIYAOWUYONGLIANGDEJIANGDIZUOYONG:ZAIYIXIANGANWEIJIDUIZHAO、GUKEJIPUWAIKESHOUSHUDEYANJIU(n=1050)ZHONG,HUANZHEJIESHOUQISHIJILIANG40mg、SUIHOU20mg,YIRILIANGCI,ZHISHAO72hZHILIAO,BINGJIESHOUBAOKUOHUANZHEZIKONGAPIANLEIYAOWUZUOWEIFUZHUZHILIAODEBIAOZHUNHUACHULI。SHIYONGBENPINZHILIAODEHUANZHEZAIDI2TIANHEDI3TIANSHIAPIANLEIYAOWUYONGLIANGFENBIEJIANSHAOLE7.2mgHE2.8mg(FENBIEJIANSHAOLE37%HE28%)。APIANLEIYAOWUYONGLIANGJIANSHAODETONGSHI,HUANZHEZIFABAOGAOAPIANLEIXIANGGUANZHENGZHUANGBUSHIYOULEXIANZHUJIANSHAO。HEDANDUYINGYONGAPIANLEIYAOWUXIANGBI,LIANHEYINGYONGPARUIXIBUKEHUODEGENGDUODETENGTONGHUANJIE。QITASHOUSHUMOXINGDEYANJIUYEKEGUANCHADAOLEISIDEJIEGUO。DANGYUAPIANLEIYAOWULIANHEYINGYONGSHI,MEIYOUSHUJUXIANSHIYINGYONGPARUIXIBUZUZONGTIBULIANGSHIJIANFASHENGLVDIYUANWEIJIZU。

   YOUGUANWEICHANGDAODELINCHUANGYANJIU:ZAIWEIQI7TIANDEDUANQILINCHUANGYANJIUZHONG,ZAISHIYONGBENPINDEQINGNIANYULAONIAN(≥65SUI)JIANKANGSHOUSHIZHEZHONG,NEIKUIJINGXIAWEIJISHIERZHICHANGKUIYANGHEZHANMOMILANDEFASHENGLVWEI5%~21%。FASHENGLVGAOYUANWEIJIZU(5%~12%),RANERXIANZHUDIYUNSAIDsZU(66%~90%)。

   GUANZHUANGDONGMAIDAQIAOSHUHOUANQUANXINGYANJIU:CHUCHANGGUIBULIANGSHIJIANBAOGAOWAI,HAIJINXINGLELIANGCIANWEIJIDUIZHAODEANQUANXINGYANJIU,DUIYOUDULIZHUANJIAWEIYUANHUIYUXIANZHIDINGSHIJIANLEIBIEJINXINGFENXI。ZAIYANJIUGUOCHENGZHONG,SHOUSHIZHESHOUXIANJIESHOUWEIQIZHISHAO3TIANDEPARUIXIBUZHILIAO,RANHOUKOUFUFADIXIBU,ZONGZHILIAOQIWEI10-14TIAN。SUOYOUSHOUSHIZHEZAIZHILIAOQIJIANJUNJIESHOUBIAOZHUNZHITONGHULI。SHOUSHIZHEZAISUIJIFENZUQIANJILIANGXIANGYANJIUGUOCHENGZHONGJUNFUYONGDIJILIANGASIPILIN。DIYIXIANGGUANZHUANGDONGMAIDAQIAOSHOUSHUYANJIUSHIWEIQI14TIANDESHUANGMANGANWEIJIDUIZHAOYANJIU。SHOUSHIZHESHOUXIANJINGMAIZHUSHEPARUIXIBUNA(40mg,YIRILIANGCI)ZHISHAO3TIAN,SUIHOUJIESHOUFADIXIBU(40mg,YIRILIANGCI,PARUIXIBUNA/FADIXIBUZU,n=311)HUOANWEIJI/ANWEIJI(n=151)。DUI9XIANGYUXIANZHIDINGDEBULIANGSHIJIANLEIBIE(BAOKUOXINXUEGUANXUESHUANSHUANSAISHIJIAN、XINBAOYAN、CHONGXUEXINGXINLISHUAIJIEDEFASHENGHUOEHUA、SHENGONGNENGSHUAIJIE/GONGNENGSUNSHANG、SHANGXIAOHUADAOKUIYANG、FEIWEICHANGDAODACHUXUE、GANRAN、FEIGANRANXINGFEIBUBINGFAZHENGJISIWANG)JINXINGPINGGU。JINGZHUJIYAOQIJIANHEQUANBUYANJIUGUOCHENGZHONG,PARUIXIBU/FADIXIBUZUXINXUEGUAN/XUESHUANSHUANSAISHIJIAN(BAOKUOXINJIGENGSI、XINJIQUEXUE、NAOXUEGUANYIWAI、SHENDUJINGMAISHUANSAIYIJIFEISHUANSAI)DEFASHENGLVJUNMINGXIANGAOYUANWEIJI/ANWEIJIZHILIAOZU(JINGZHUJIYAOQIJIANFENBIEWEI2.2%HE0.0%;QUANBUYANJIUQIJIANFENBIEWEI4.8%HE1.3%)。PARUIXIBU/FADIXIBUZUSHOUSHUSHANGKOUBINGFAZHENG(ZHUYAOSHIXIONGGUSHANGKOU)FASHENGLVZENGGAO。DIERXIANGGUANZHUANGDONGMAIDAQIAOSHOUSHUYANJIU,DUISILEIYUXIANZHIDINGBULIANGSHIJIAN(BAOKUOXINXUEGUAN/XUESHUANSHUANSAI、SHENGONGNENGYICHANG/SHENGONGNENGSHUAIJIE、SHANGXIAOHUADAOKUIYANG/CHUXUE、SHOUSHUSHANGKOUBINGFAZHENG)JINXINGPINGGU。BINGRENZAIGUANZHUANGDONGMAIDAQIAOSHUHOU24XIAOSHINEIBEISUIJIFENZU:PARUIXIBU/FADIXIBUZU(PARUIXIBUJINGZHUQISHIJILIANG40mg,SUIHOUJINGZHUPARUIXIBU20mg,MEIRI2CI,ZHISHAO3TIAN,JIEZHEKOUFUFADIXIBU20mg ,MEIRI2CI,WEICHIZHILIAO10TIAN)(n=544);ANWEIJI/FADIXIBUZU(JINGZHUANWEIJI,SUIHOUKOUFUFADIXIBU)(n=544);HUOZHEANWEIJI/ANWEIJIZU(JINGZHUANWEIJI,SUIHOUKOUFUANWEIJI)(n=548)。PINGGUJIEGUOBIAOMING:PARUIXIBU/FADIXIBUZHILIAOZU(2.0%)XINXUEGUAN/XUEGUANSHUANSAILEISHIJIANDEFASHENGLVMINGXIANGAOYUANWEIJI/ANWEIJIZU (0.5%) (P=0.033)。ANWEIJI/FADIXIBUZHILIAOZUXINXUEGUANXUESHUANSHUANSAISHIJIANDEFASHENGLVGAOYUANWEIJI/ANWEIJIZU,DANBUJUYOUXIANZHUTONGJIXUECHAYI。ANWEIJI/FADIXIBUZHILIAOZUGONGFASHENG6LIXINXUEGUANXUESHUANSHUANSAISHIJIAN,QIZHONG3LIFASHENGZAIANWEIJIZHILIAOQIJIAN。ZHEIXIEHUANZHEMEIYOUJIESHOUFADIXIBUZHILIAO。ZAISUOYOUSANZUZHILIAOZUZHONG,YUXIANZHIDINGSHIJIANFASHENGLVZUIGAODESHISHOUSHUSHANGKOUBINGFAZHENG,BAOKUOSHENBUSHOUSHUGANRANJIXIONGGUSHANGKOUYUHESHIJIAN。ZHILIAOZUHEANWEIJIZUZAIQITASHIJIANLEIBIE(SHENGONGNENGYICHANG/SHENGONGNENGSHUAIJIE,SHANGWEICHANGDAOKUIYANGBINGFAZHENGHUOSHOUSHUSHANGKOUBINGFAZHENG)DEFASHENGLVSHANGMEIYOUXIANZHUXINGCHAYI。

   CHANGGUISHOUSHU:DAGUIMOGUKE/PUWAIKESHOUSHUYANJIUZHONG(n=1050),HUANZHEJIESHOUJINGZHUPARUIXIBUZHILIAO,QISHIJILIANGWEI40mg,SUIHOUJINGZHU20mg,MEIRI2CI,ZHISHAO3TIAN,ZAIKOUFUFADIXIBU20mg,MEIRI2CI,WEICHIZHILIAO10TIAN(n=525),HUOZHEXIANJINGZHUANWEIJI,SUIHOUKOUFUANWEIJI(n=525)。LIANGZUZAISUOYOUANQUANXINGZILIAOFANGMIANMEIYOUXIANZHUXINGCHAYI,QIZHONGBAOKUOSHANGSHUDIERCIGUANZHUANGDONGMAIDAQIAOSHUYANJIUZHONGDESIXIANGYUXIANZHIDINGDESHIJIANLEIBIE。

   YOUGUANXUEXIAOBANDELINCHUANGYANJIU:ZAIYIXILIEXIAOXING、DUOCIJIYAODELINCHUANGYANJIUZHONG,JIYUQINGNIANYULAONIANJIANKANGSHOUSHIZHEPARUIXIBU20mgHUO40mg,YITIANLIANGCI。YUANWEIJIZUXIANGBI,PARUIXIBUDUIXUEXIAOBANJUJIHUOCHUXUEMEIYOUYINGXIANG。ZAIQINGNIANSHOUSHIZHEZHONG,PARUIXIBU(YICI40mg,YITIANLIANGCI)DUIASIPILINJIEDAODEXUEXIAOBANGONGNENGYIZHIMEIYOULINCHUANGXIANZHUYINGXIANG。

  【YAOLIDULI】YAOLIZUOYONG PARUIXIBUSHIFADIXIBUDEQIANTIYAOWU。FADIXIBUZAILINCHUANGJILIANGFANWEISHIXUANZEXINGCOX-2YIZHIJI。

YABOTIYUapp:   DULIYANJIU

   YICHUANDUXING PARUIXIBUAmesSHIYAN、CHO/HGPRTBURUDONGWUXIBAOJIYINTUBIANSHIYAN、DASHUTINEIGUSUIWEIHESHIYANJIEGUOWEIYINXING;CHOXIBAORANSETIJIBIANSHIYANZHONG,PARUIXIBUZAIYOUHUOWUS9(DASHUGANZANGWEILITI)TIAOJIANXIAZUOYONG4XIAOSHIJIEGUOWEIYANGXING,ZAIWUS9TIAOJIANXIAZUOYONG24XIAOSHIJIEGUOWEIYINXING。

   SHENGZHIDUXING RENSHENTUJIYUPARUIXIBU,ZAIBUYINQIMUTIDUXINGDEJILIANGSHIKEJIANZHECHUANGHOUDIUSHI、XISHOUTAIYIJITAIZITIZHONGZENGZHANGCHIZHI。PARUIXIBUDUIXIONGXINGHUOCIXINGDASHUSHENGYULIWEIJIANYINGXIANG。SHANGWEIPINGJIAPARUIXIBUDUIRENSHENWANQIHUOWEICHANQIDEYINGXIANG。BURUQIDASHUDANCIJINGMAIZHUSHEJIYUPARUIXIBU,RUZHIZHONGDEPARUIXIBU、FADIXIBUYIJIFADIXIBUHUOXINGDAIXIEWUDENONGDUYUMUTIXUEJIANGNONGDUXIANGSI。

YABOTIYUapp:   ZHIAIXING SHANGWEIPINGJIAPARUIXIBUDEZHIAIXING。

  【YAODAIDONGLIXUE】PARUIXIBUZAIJINGZHUHUOJIZHUHOUJINGGANZANGMEISHUIJIE,XUNSUZHUANHUAWEIYOUYAOLIXUEHUOXINGDEWUZHI——FADIXIBU。

   XISHOU BENPINDANCIJIYAOHOU,ZAILINCHUANGJILIANGFANWEINEI,YIXUEYAONONGDU-SHIJIANQUXIANXIAMIANJI(AUC)YIJIFENGNONGDU(Cmax)LIANGXIANGZHIBIAODAIBIAODEFADIXIBUDEBAOLUSHUIPINGJINSIXIANXINGBIAODA。PARUIXIBUYITIANJIYAOLIANGCI,JINGZHUJILIANGBUCHAOGUO50mgJIJIZHUJILIANGBUCHAOGUO20mgDEQINGKUANGXIA,QIAUCYUCmaxZHIJIANCHENGXIANXIANXINGGUANXI。PARUIXIBUYITIANJIYAOLIANGCI,ZAI4TIANNEIKEDADAOFADIXIBUDEWENTAIXUEYAONONGDU。PARUIXIBUDANCIJINGZHUHUOJIZHU20mg,FADIXIBUFENBIEYUZHUSHEHOUYUE30FENZHONGHUO1XIAOSHIDADAOFENGNONGDU。JINGMAIJIYAOHUOJINEIZHUSHEJIYAO,FADIXIBUDEBAOLUSHUIPING(AUCJICmax)JIBENXIANGTONG。JINGZHUHUOJIZHUHOU,PARUIXIBUDEBAOLUSHUIPINGJIBENXIANGTONG(AUC);DANJIZHUHOUDEPARUIXIBUPINGJUNCmaxDIYUJINGZHUHOUDEPINGJUNCmax,ZHEIKENENGYUJIZHUHOUYAOWUZAIXUEGUANWAIXISHOUJIAOMANYOUGUAN。YOUYUJINGZHUHUOJIZHUPARUIXIBUHOUFADIXIBUDEFENGNONGDUJIBENYIZHI,YINCISHANGSHUCHABIEBINGWUZHONGYAOLINCHUANGYIYI。

   FENBU JINGZHUHOU,FADIXIBUDEFENBURONGJIYUEWEI55SHENG。XUEJIANGDANBAIJIEHELVZAIZUIGAOTUIJIANJILIANG(80mg/TIAN)SHIDADAO98%。FADIXIBU

YABOTIYUapp:(ERFEIPARUIXIBU)KEGUANGFANFENBUYUHONGXIBAONEI。

   DAIXIE PARUIXIBUZAITINEIKUAISUBINGJIHUWANQUANDIZHUANHUAWEIFADIXIBUHEBINGSUAN,XUEJIANGBANSHUAIQIYUEWEI22FENZHONG。FADIXIBUDEXIAOCHUZAIGANZANGNEITONGGUODUOZHONGTUJINGGUANGFANJINXING,BAOKUOXIBAOSESUP450(CYP)3A4YUCYP2C9TONGGONGMEIDAIXIEYIJIHUANGANPUTAOTANGQUANSUANHUA(YUE20%)。YIZAIRENTIXUEJIANGZHONGQUERENFADIXIBUDEYIZHONGQIANGHUADAIXIEWU(JINGCYPTUJINGDAIXIE)YEJUYOUYIZHICOX-2ZUOYONG,TADETINEINONGDUXIANGDANGYUFADIXIBUNONGDUDEYUE10%。YOUYUZHEIZHONGDAIXIEWUDENONGDUJIAODI,YINCIJIYUZHILIAOJILIANGPARUIXIBUHOU,BINGBUQIWANGZHEIZHONGDAIXIEWUFAHUIZHONGYAODELINCHUANGZUOYONG。

   XIAOCHU FADIXIBUZHUYAOZAIGANZANGNEIXIAOCHU,SHAOYU5%DEFADIXIBUTONGGUONIAOYEYIYUANXINGXINGSHIPAIXIE。NIAOYEZHONGWEIJIANCEDAOPARUIXIBUDEYUANXINGWUZHI,FENBIANZHONGJINJIANCEDAOHENLIANGYUANXINGWUZHI。JIYAOHOU,YUE70%DEYAOWUYIFEIHUOXINGDAIXIEWUXINGSHIJINGNIAOPAIXIE。FADIXIBUDEXUEJIANGQINGCHULV(CLp)YUEWEI6L/XIAOSHI。JINGZHUHUOJIZHUPARUIXIBUNAHOU,FADIXIBUDEXIAOCHUBANSHUAIQI(t1/2)YUEWEI8XIAOSHI。

   LAONIANREN:ZAIYAODAIDONGLIXUEYULINCHUANGZHILIAOYANJIUZHONG,335LILAONIANHUANZHE(65~96SUI)JIESHOUBENPINZHILIAO。ZAIJIANKANGLAONIANSHOUSHIZHEZHONG,YOUYUFADIXIBUKOUFUBIAOGUANQINGCHULVJIANGDI,DAOZHIFADIXIBUXUEJIANGBAOLUSHUIPINGJIAOJIANKANGNIANQINGSHOUSHIZHESHENGGAOYUE40%。XIAOZHENGTIZHONGHOU,LAONIANNVXINGSHOUSHIZHEDEFADIXIBUWENTAIXUEYAONONGDUJIAOLAONIANNANXINGGAO16%。

   SHENGONGNENGSUNSHANG:BUTONGCHENGDUSHENGONGNENGSUNSHANGDEHUANZHEJINGZHUPARUIXIBU20mgHOU,PARUIXIBUJUNCONGXUEJIANGZHONGKUAISUQINGCHU。YOUYUSHENZANGXIAOCHUBUSHIFADIXIBUZHUYAODEXIAOCHUTUJING,JISHIZAIYANZHONGSHENGONGNENGSUNSHANGHUOYILAITOUXIDEHUANZHEZHONGYEWEIFAXIANFADIXIBUQINGCHULVDEGAIBIAN。

   GANGONGNENGSUNSHANG:ZHONGDUGANGONGNENGSUNSHANGBINGBUYINQIPARUIXIBU-FADIXIBUZHUANHUANSULVHUOZHUANHUANCHENGDUDEJIANGDI。DUIYUZHONGDUGANGONGNENGSUNSHANGDEHUANZHE(Child-Pugh PINGFEN:7~9),YOUYUFADIXIBUDEBAOLUSHUIPINGKESHENGGAOZHIZHENGCHANGFANWEIDELIANGBEIYISHANG(+130%),GUPARUIXIBUDECHUSHIJILIANGYINGJIANZHICHANGGUITUIJIANLIANGDEERFENZHIYI,QIEMEIRIZUIGAOJILIANGJIANGZHI40mg。MUQIANSHANGWEIDUIYANZHONGGANGONGNENGSUNSHANGHUANZHEDEYONGYAOZHUANGKUANGJINXINGYANJIU,YINCIBUTUIJIANZHEILEIHUANZHESHIYONGPARUIXIBU。

YABOTIYUapp:【ZHU    ZANG】MIBIBAOCUN。PEIZHIHOUDEYAOYEJINGONGDANCISHIYONG,BUDELENGDONGHUOLENGZANG。

【BAO    ZHUANG】ZHONGPENGGUIBOLIGUANZHIZHUSHEJIPING,LENGDONGGANZAOZHUSHEYONGWUJUNFENMOYONGXIUHUADINGJIXIANGJIAOSAI。

            BAOZHUANGGUIGE:1PING/HE、2PING/HE、5PING/HE、10PING/HE。

YABOTIYUapp:【YOU XIAO QI】12GEYUE

YABOTIYUapp:【ZHIXINGBIAOZHUN】YBH02872019

YABOTIYUapp:【PIZHUNWENHAO】(1)20mg:GUOYAOZHUNZIH20193380 (2)40mg:GUOYAOZHUNZIH20193381

YABOTIYUapp:【SHENGCHANQIYE】

YABOTIYUapp:   QIYEMINGCHENG:SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSI

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   DIANHUAHAOMA:0539-8257899  8481991               CHUANZHENHAOMA:0539-8481990

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亚博体育app:

【SHIYINGZHENG】YONGYUSHOUSHUHOUTENGTONGDEDUANQIZHILIAO。ZAIJUEDINGSHIYONGXUANZEXINGHUANYANGHUAMEI-2(COX-2)YIZHIJIQIAN,YINGPINGGUHUANZHEDEZHENGTIFENGXIAN。

亚博体育app:

【YONGFAYONGLIANG】TUIJIANJILIANGWEI40mgJINGMAIZHUSHE(IV)HUOJINEIZHUSHE(IM)JIYAO,SUIHOUSHIXUYAOJIANGE6~12XIAOSHIJIYU20mgHUO40mg,MEITIANZONGJILIANGBUCHAO80mg。YOUYUXUANZEXINGCOX-2YIZHIJIDEXINXUEGUANSHIJIANFASHENGFENGXIANSUIZHEJILIANGJIBAOLUSHIJIANZENGJIAERZENGJIA,YINCI,YINGJINKENENGSHIYONGZUIDUANLIAOCHENGJIZUIDIMEIRIYOUXIAOJILIANG。SHIYONGBENPINCHAOGUOSANTIANDELINCHUANGJINGYANYOUXIAN。KEZHIJIEJINXINGKUAISUJINGMAITUIZHU,HUOTONGGUOYIYOUJINGMAITONGLUJIYAO。JINEIZHUSHEYINGXUANZESHENBUJIROUHUANMANTUIZHU。YOUYUBENPINYUQITAYAOWUZAIRONGYEZHONGHUNHEKECHUXIANCHENDIAN,YINCIBULUNZAIRONGJIEHUOSHIZHUSHEGUOCHENGZHONG,BENPINYANJINYUQITAYAOWUHUNHE。RUPARUIXIBUYUQITAYAOWUSHIYONGTONGYITIAOJINGMAITONGLU,PARUIXIBURONGYEZHUSHEQIANHOUXUCAIYONGXIANGRONGRONGYECHONGFENCHONGXIJINGMAITONGLU。

   YUAPIANLEIZHENTONGYAOLIANHEYONGYAO:APIANLEIZHENTONGYAOKEYIYUPARUIXIBUTONGSHIYINGYONG,BENPINSHIYONGJILIANGCANJIANSHANGWEN。ZAISUOYOUDELINCHUANGPINGGUZHONG,PARUIXIBUSHIGUDINGJIANGESHIJIANJIYAO,ERAPIANLEIYAOWUZESHIANXUJIYAO。

   LAONIANHUANZHE:TONGCHANG,DUIYULAONIANHUANZHE(≥65SUI)BUBIJINXINGJILIANGDIAOZHENG。DANSHI,DUIYUTIZHONGDIYU50kgDELAONIANHUANZHE,BENPINDECHUSHIJILIANGYINGJIANZHICHANGGUITUIJIANJILIANGDEYIBANQIEMEIRIZUIGAOJILIANGYINGJIANZHI40mg。

   GANGONGNENGSUNSHANG:MUQIANSHANGWUYANZHONGGANGONGNENGSUNSHANGHUANZHE(Child-Pugh PINGFEN:≥10)DELINCHUANGYONGYAOJINGYAN,YINCIJINZHIZAICILEIHUANZHEZHONGSHIYONGPARUIXIBU。TONGCHANG,QINGDUGANGONGNENGSUNSHANGDEHUANZHE(Child-Pugh PINGFEN:5~6)BUBIJINXINGJILIANGDIAOZHENG。ZHONGDUGANGONGNENGSUNSHANGDEHUANZHE(Child-Pugh PINGFEN:7~9)YINGSHENYONGBENPIN,JILIANGYINGJIANZHICHANGGUITUIJIANJILIANGDEYIBANQIEMEIRIZUIGAOJILIANGJIANGZHI40mg。

   SHENGONGNENGSUNSHANG:DUIYUZHONGDUSHENGONGNENGSUNSHANG(JIGANQINGCHULV:<30ml/min)HUOYOUYETIZHULIUQINGXIANGDEHUANZHE,YINGXUANZEZUIDITUIJIANJILIANG(20mg)KAISHIZHILIAOBINGMIQIEJIANCESHENGONGNENG。YIJUPARUIXIBUDEYAODAIDONGLIXUE,BUBIDUIQINGDUZHIZHONGDUSHENGONGNENGSUNSHANG(JIGANQINGCHULV:30~80ml/min)DEHUANZHEJINXINGJILIANGDIAOZHENG。

   ERTONGYONGYAO:SHANGWEIQUEDING18SUIYIXIAERTONGSHIYONGPARUIXIBUDEANQUANHELIAOXIAO。MUQIANSHANGWUKEYONGSHUJU。YINCI,BUTUIJIANZAICILEIRENQUNZHONGSHIYONGPARUIXIBU。

   SHIYONGYUCHUZHI(BAOKUODIUQI)ZHIDAOSHUOMING ZHUSHEYONGPARUIXIBUNASHIYONGQIANBIXUZHONGXINPEIZHI。YOUYUBUHANFANGFUJI。YINCIYAOQIUCAIYONGWUJUNJISHUJINXINGPEIZHI。

   PEIZHIRONGJI:KEYONGYUPEIZHIZHUSHEYONGPARUIXIBUNADERONGJIBAOKUO:LVHUANARONGYE9mg/ml(0.9%);PUTAOTANGZHUSHEYE50mg/ml(5%);LVHUANA4.5mg/ml(0.45%)PUTAOTANG50mg/ml(5%)ZHUSHEYE。

   PEIZHIGUOCHENG CAIYONGWUJUNJISHUPEIZHIPARUIXIBUDONGGANFEN(JIPARUIXIBU)。QUCHUQIKOUGAI,BAOLUPARUIXIBUBOLIPINGXIANGJIAOPINGSAIDEZHONGYANGBUFEN。YONGWUJUNZHUSHEQIJIZHENTOUXIQUSHIYONGRONGJI(20mgPARUIXIBUNAYONG1mlRONGJIPEIZHI,40mgPARUIXIBUNAYONG2mlRONGJIPEIZHI),RANHOUJIANGZHENTOUCHAJINXIANGJIAOPINGSAIZHONGYANGXIANGPINGNEIZHURURONGJI。QINGQINGXUANZHUANPINGTISHIFENMOWANQUANRONGJIEBINGZAISHIYONGQIANZIXIJIANCHAPEIZHICHENGDERONGYE。JIANGPINGNEIQUANBUYAOYECHOUCHUGONGDANCIJIYAO。PEIZHIHOU,YAOYEYINGWEITOUMINGRONGYE。PARUIXIBUNARONGYEYINGZAISHIYONGQIANJINXINGMUCE,QUEDINGRONGYESHIFOUYOUBURONGXINGWEILIHUOFASHENGBIANSE。RUOGUANCHADAORONGYEFASHENGBIANSE,CHUXIANXUZHUANGWUHUOBURONGXINGWEILI,ZEBUDESHIYONG。PEIZHIHOU,PARUIXIBUNARONGYEYINGZAI24XIAOSHINEISHIYONG,FOUZEYINGFEIQI。YIJINGZHENGSHIZAI25℃TIAOJIANXIA,PEIZHIHOUYAOYE(BUDELENGZANGHUOLENGDONG)DEWULI、HUAXUEWENDINGXINGZUIZHANGKEBAOCHI24XIAOSHI。YINCI,24XIAOSHIYINGBEISHIWEIYAOWUPEIZHIHOUDEZUIZHANGYOUXIAOQI。RANER,YOUYUZHUSHECHANPINYOUWEISHENGWUGANRANDEZHONGYAOFENGXIAN,YINCIPEIZHIDERONGYEYINGLIJISHIYONG,CHUFEIRONGYEDEPEIZHISHIZAIYANGEKONGZHIDE、BINGJINGGUOYANZHENGDEWUJUNHUANJINGZHONGJINXING。CHUFEIMANZUSHANGSHUTIAOJIAN,FOUZESHIYONGZHEBIXUZAISHIYONGQIANKONGZHIQIZHUZANGSHIJIANYUTIAOJIAN。YIBANLAISHUO,ZAI25℃TIAOJIANXIABAOCUNBUYINGCHAOGUO12XIAOSHI。PEIZHIHOUDEPARUIXIBUNARONGYEWEIDENGSHENRONGYE。

   JINGMAITONGLURONGYEDEXIANGRONGXING CAIYONGSHIYONGRONGYEPEIZHIHOU,PARUIXIBUNARONGYEZHINENGYIJINGMAIZHUSHE、JIROUZHUSHE、HUOJIARUXIALIEYETIDEJINGMAITONGLUJIYAO:LVHUANAZHUSHEYE9mg/ml(0.9%) PUTAOTANGZHUSHEYE50mg/ml(5%) LVHUANA4.5mg/ml(0.45%)HEPUTAOTANG50mg/ml(5%) ZHUSHEYE RUSUANLINGESHIYE YOUYUKEYIDAOZHIPARUIXIBUZAIRONGYEZHONGCHENDIAN,GUBUTUIJIANXIANGHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEHUOQITAWEILIECHURONGYEDEJINGMAITONGLUZHONGJIARUPARUIXIBU。PEIZHIHOUDEYAOYEJINGONGDANCISHIYONG。RENHEPEIZHIHOUWEISHIYONGDEYIYAOCHANPINHUOFEIQIWUPINDOUYINGDANGANZHAODANGDIYAOQIUYUYICHULI。

   YAOWUDEBUXIANGRONGXING CHU[SHIYONGYUCHUZHI(BAOKUODIUQI)ZHIDAOSHUOMING]SUOLIEYAOWUWAI,PARUIXIBUBUDEYUQITARENHEYAOWUHUNHE。BENPINBUYINGYUAPIANLEIYAOWUHUNHEYUTONGYIZHUSHEQINEIJIYAO。SHIYONGRUSUANLINGESHIYEHUOHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEPEIZHI,PARUIXIBUHUIZAIRONGYEZHONGFASHENGCHENDIAN,GUBUTUIJIANSHIYONG。BUTUIJIANSHIYONGZHUSHEYONGSHUI,YINWEIDEDAODERONGYEBUDENGSHEN。PARUIXIBUNARONGYEBUYINGZHURURENHEQITAYAOWUDEJINGMAITONGLU。PARUIXIBUNARONGYEZHUSHEQIANHOUYINGYONGXIANGRONGRONGYECHONGFENCHONGXIJINGMAITONGLU。YOUYUKEYIDAOZHIPARUIXIBUZAIRONGYEZHONGCHENDIAN,GUBUTUIJIANXIANGHAN50mg/ml(5%)PUTAOTANGDERUSUANLINGESHIYEHUOQITA[SHIYONGYUCHUZHI(BAOKUODIUQI)DEZHIDAO]ZHONGWEILIECHURONGYEDEJINGMAITONGLUZHONGJIARUPARUIXIBU。

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